Macros not working

Macros don’t work on my PC unless I deactivate/reactivate the macros after every PC restart. I have tried running stable/beta, no change. I have tried running administrator and manually opening Signal upon restart, no change. As soon as I turn macros off and back on they work as intended. If I have to open signal to make the macros work, I could just change my effect then and defeats the purpose of macros all together. My 4 macros used are cntrl + 1-4. As stated it works when turning them off/on so it shouldn’t be a focused window issue.