The “Ctrl + Shift + Delete” keypress/keystroke is common to most Internet browsers when clearing browser cache, cookies, etc. and when performed this also disables the macros feature of SignalRGB in the process.
I propose a checkbox or settings toggle to allow disablement of the “Macros Disabled” toggle or its “Ctrl + Shift + Delete” actuation sequence. Also, allowing customization of the actuation keypress/keystroke for this feature would be a solution to this issue.